Experts worry that antivirals may mask avian influenza

first_imgAug 24, 2006 (CIDRAP News) – Avian flu experts in two of the countries with the most human H5N1 avian influenza cases to date—Vietnam and Thailand—are warning that the antiviral drug oseltamivir may mask the infection and complicate laboratory detection.Menno de Jong, a virologist at an Oxford University clinical research unit in Ho Chi Minh City, Vietnam, told Bloomberg News this week that avian influenza may go undetected in patients who take the drug days before testing. An incorrect diagnosis is problematic because it may hamper early detection of disease spread.Some countries are responding to local human H5N1 avian influenza outbreaks by distributing oseltamivir to local citizens. For example, the Jakarta Post reported this week that Indonesia’s health ministry had distributed the drug to 2,100 villagers in Garut, a district in West Java, Indonesia, where three recent cases have been documented and authorities are investigating the possibility of human-to-human transmission.Antiviral drugs such as oseltamivir are designed to reduce the duration of viral replication and should be taken within 48 hours of symptom onset, according to World Health Organization (WHO) recommendations. However, De Jong’s team, which observed 18 cases in Vietnam, found that analysis of nasal and throat swabs taken from patients 48 to 72 hours after beginning oseltamivir treatment was unable to detect the virus.A study of Vietnamese H5N1 cases in a September 2005 issue of The New England Journal of Medicine found that genetic evidence of the H5N1 virus could not be detected in throat swab samples until between 2 and 15 days (median 5.5 days) after illness onset.”If a patient is on oseltamivir for 3 days before the first swab is taken for diagnostic testing, it’s possible the result will be negative, but the patient could be infected,” he told Bloomberg News.To prevent the drug from masking a possible H5N1 virus infection, he advises that patients undergo testing before or soon after taking oseltamivir. Obtaining a swab sample from the patient takes only seconds and should not delay the patient’s treatment, de Jong said.Meanwhile, a public health official in Thailand expressed the same concerns about possible false-negative testing results for the H5N1 virus in patients who take oseltamivir. In an article that appeared in The Nation, a Thai daily newspaper, Paijit Warachit, director-general of the Department of Medical Sciences, said that initial laboratory tests did not detect the H5N1 virus in the country’s two most recent cases.Warachit said the disease progression may be becoming more complicated in humans, or the use of oseltamivir could be complicating the patients’ lab results. He noted that the drug is able only to prevent the virus from replicating, not destroy it, and that little of the virus was in the patients’ respiratory tract for testing.With the last two Thai cases, the avian influenza virus was found to be deeper in the respiratory tract than is typically found with other influenza viruses. Warachit said the medical staff has been told to probe deeper to obtain a complete testing specimen.Since 2004 Thailand’s health ministry has tested more than 4,000 people for the H5N1 avian influenza virus, with a 3% failure rate. However, Warachit said the failure rate has risen to 20% this year. “We need to continue our studies to see whether the virus will become more and more difficult [to detect] in the future,” he noted.See also:Sep 29, 2005, New England Journal of Medicine article on avian influenza in humanshttp://content.nejm.org/cgi/content/full/353/13/1374last_img read more

Miss America

first_imgI guess I have lost my campaign against tattoos when a Miss America candidate makes the finals with a very visible tattoo.  If the Miss America pageant doesn’t have a problem with a tattoo, I guess pro-sports, college sports, and high school sports won’t do anything about it either.  I do not find tattoos making anyone look more athletic or macho.  What I see is some hideous ink marring a young body for life.  Sure, LeBron James looks ferocious on a basketball floor now, but what will he look like in 15 years working in some office or representing some company at a business conference?  It used to be that you put tattoos where they could be covered, but now they put them all over their body and it is impossible to cover them all up.  To add to that, the many forms of long hair tied in various knots again does not make them look like an athlete, but like some unkempt bum off the street.  Peyton Manning seems to do quite well without the tattoos, long hair, lip rings, and what have you as Michael Strahan did in his era.  Let’s just hope that our young athletes choose to follow Manning and Strahan instead of a Dennis Rodman.last_img read more

State Tournament Formats

first_imgHave you noticed how different the state tournament format is in Indiana for different sports?  Several of the sports have the traditional 4-week format.  This includes basketball and football, of course.  Then there is the group that have a 3-week tournament series.  This group is headed up by track.  The most unfair system, I think, is the swimming format.  In this sport, you go directly to the state from the sectionals.  This in itself sounds like a good deal until you see that only the top 2 performers in the sectional get to go to the state.  This means that in the sectional that our area schools go to almost every spot is taken by the Columbus and Bloomington schools.  If you are a traditional 1A or 2A school, you only have an athlete good enough to get out of the sectional every 25 years or so.  I really don’t understand why the state doesn’t add at least one more level to the series for swimming.  That is why the job that Coach Green at Batesville has done with his program is so phenomenal.  Even 4A East Central seldom qualifies swimmers for the state.last_img read more

Ronaldo close to another record

first_img read also:Ronaldo committed to Juve The 35-year-old, who arrived at Juventus in July 2018, scored 84 goals in the Premier League with Manchester United and 311 goals in La Liga during his time with Real Madrid. Edin Dzeko became the first player ever to score at least 50 goals in three of Europe’s top five Leagues in March 2018, reaching the milestone in Italy, England and Germany. FacebookTwitterWhatsAppEmail分享 Loading… Juventus talisman, Cristiano Ronaldo, could become the first player in history to score at least 50 goals in the Premier League, La Liga, and Serie A when the Old Lady face Sassuolo tomorrow. The Portuguese superstar is on the verge of reaching yet another milestone, as he’s currently on 49 goals in the Italian League. Sportmediaset writes that since he has scored them in only 59 matches it can also help him become the fastest to reach 50 goals in Serie A. Ronaldo reached his 50th goal in Italy after 70 games, only beaten by Andriy Schevchenko, who is still the quickest with 69 games.Advertisementcenter_img Promoted Content7 Theories About The Death Of Our UniverseWho Earns More Than Ronaldo?6 Ridiculous Health Myths That Are Actually TrueCouples Who Celebrated Their Union In A Unique, Unforgettable Way10 Risky Jobs Some Women DoDid You Know There’s A Black Hole In The Milky Way?Who Is The Most Powerful Woman On Earth?20 Completely Unexpected Facts About ‘The Big Bang Theory’7 Ways To Understand Your Girlfriend BetterBest Car Manufacturers In The WorldBirds Enjoy Living In A Gallery Space Created For ThemHere Are The Top 10 Tiniest Mobile Phones On The Planet!last_img read more

Formula One’s governing body says Shanghai Grand Prix scheduled for April postponed due to virus

first_imgFormula One’s governing body says Shanghai Grand Prix scheduled for April postponed due to virus February 12, 2020 Associated Press center_img Share This StoryFacebookTwitteremailPrintLinkedinRedditLONDON (AP) — Formula One’s governing body says Shanghai Grand Prix scheduled for April postponed due to virus.last_img

Pryor is a real handful

first_imgAny conversation about the 2009 Ohio State football team has to begin and end not with coach Jim Tressel’s sweater vest, but supremely talented quarterback Terrelle Pryor. The 2008 No. 1 recruit in the country, Pryor boasts a skill set that already has NFL executives drooling.“He’s a great player. He’s a focal point guy. You can’t watch [Ohio State] and not watch him,” coach Pete Carroll said during his weekly press conference.Game changer · The Trojans’ gameplan will be centered on stopping elusive Ohio State quarterback Terrelle Pryor, who has improved from 2008. – Eric Wolfe | Daily TrojanDual-threat quarterbacks like Dennis Dixon and Vince Young have given the USC defense fits in the past with their scrambling ability, and Pryor has more raw talent than either of them.“I’ve always said that the most difficult aspect of defending an opponent is when they have a quarterback that can run and run on plays that aren’t designed to be quarterback running plays,” Carroll said.Pryor himself played well last season against USC in relief of starting quarterback Todd Boeckman. While the lead-footed Boeckman was hopeless in the face of the Trojans’ pass rush, Pryor completed seven of nine passes for 52 yards and added another 40 yards on the ground. With another year of seasoning he should provide a stiff challenge for the revamped Trojans defense.The 6-foot-6, 235-pound Pryor is more than just an agile pair of legs, however. The sophomore spent so much time this summer working on his passing that he developed tendonitis in his right arm. His arm, since healed and improved, could help Pryor emerge this year as one of the nation’s best quarterbacks.“This is a very, very unusual athlete to be this tall and this fast and have a great arm,” Carroll said. “I think you’ll see he’s not just a runner.”Here is a brief primer on some of the other names USC should be wary of this weekend.Daniel “Boom” Herron, Soph. RB, 5-foot-10, 193 lbs. and Brandon Saine, Jr. RB, 6-foot-1, 217 lbs.Running backs Daniel “Boom” Herron and Brandon Saine have the unenviable task of trying to replace Chris “Beanie” Wells, who left a year early for the NFL. The duo combined for 125 yards and a touchdown on 26 carries last week for the Buckeyes.Last season, Herron and Saine were largely ineffective against USC in place of the injured Wells, gaining just 61 yards on 13 carries. Ohio State needs to get more production from their running game outside of Pryor to take pressure off of the quarterback.Brian Rolle, Jr. LB, 5-11, 221lbs.Linebacker Brian Rolle racked up nine tackles including a tackle for loss last weekend against Navy, but it was his interception late in the game that thrust him to the forefront of the rebuilding Ohio State defense. Rolle stepped in front of a pass on a two-point conversion attempt and returned it the other way 99 yards for two points, preserving the Buckeyes victory and likely saving their season.If last week’s six-touchdown performance is any indication, the Trojans plan to ease quarterback Matt Barkley along while relying on the ground game. With three-time All-American linebacker James Laurinaitis gone, it will be up to Rolle and the other new starting linebackers to slow down USC’s stable of running backs.“The [linebackers] are real active. They run sideline to sideline. They’re just new players like our guys are,” Carroll said. “But, like our guys, they’re very athletic, and they can do all the same stuff. It’s just a matter of them gaining experience and all.”Thaddeus Gibson, Jr. DE, 6-foot-2, 240 lbs.Defensive end Thaddeus Gibson is the best NFL talent Ohio State has on that side of the ball and will be counted on to get pressure on Barkley and the USC passing game. Gibson does not have great size or strength for his position, but he combines shifty moves with excellent speed around the edge.USC’s offensive line was dominant last week against an outclassed opponent and will need to be so again this weekend. The return of center Kristofer O’Dowd, the unit’s anchor, should help the line protect Barkley, but they will need to be on their game to keep Gibson out of the backfield. If he can make Barkley uncomfortable in the pocket, the Buckeyes’ chances in the game improve drastically.last_img read more

AgiproNews’ Italian View: Leadership tries to convince coalition of maintaining betting reforms

first_img Italian bookmakers face cruel summer as ADM sanctions shop closures July 27, 2020 Share Submit Italy’s betting market continues to grow, despite facing a number of future obstacles combined with further regulatory uncertainties under the governance of the Lega-5Star coalition government.During August, Italian betting recorded total gross-gaming-revenues (GGR) of €111 million, representing a 34% increase on corresponding 2017 results.A breakdown of August GGR figures sees growth in retail betting to €61 million (+41%), whilst licensed online betting operators recorded combined revenues of €50 million (+27%).Year-to-date, total sports betting GGR has reached €963 million, reflecting €552 million wagered in betting shops (+ 43%) and €411 million (+ 41%) wagered on authorized websites.Though betting leadership will be somewhat comforted by this growth data, it will not be reassured by Lega-5Star’s latest actions related to governing the Italian gambling sector.At present, it appears that the coalition will halt the progress of Italy revamping its operational framework for sports betting, which would have introduced new directives/requirements on cash-out functionalities and Asian handicap markets.Italian stakeholders had anticipated the operational revamp to be delivered by H2 2018, as Italy moved to expand its sports betting market with a number of new bookmaker licensees.Nevertheless, it now appears that betting leadership is back to square one, having to convince new Italian Minister of Economy Giovanni Tria that changes and reforms are wholly necessary.Anxious nerves will be further agitated by Italian Deputy PM Luigi Di Maio’s most recent verbal attack on the gambling sector, declaring ‘bad blood between the new majority and the industry’ during a Parliamentary hearing.Not holding back, Di Maio has further advised that Lega-5Star should introduce tougher legislation on bookmaker licences and slot machines allocations, set forth in Italy’s upcoming Budget review._____________Content provided by AgiproNews Italia Share CT Gaming bolsters Italian profile with The Betting Coach  August 27, 2020 TVBET passes GLI test for five live games in Malta and Italy August 25, 2020 Related Articles StumbleUponlast_img read more

Rangers’ Asdrúbal Cabrera suspended 4 games for throwing batting gloves

first_imgMLB has suspended Rangers third baseman Asdrúbal Cabrera four games for his behavior after his ejection from Thursday’s win against the Indians.According to MLB.com, Cabrera plans to appeal. He has also been fined an undisclosed sum. Asdrúbal Cabrera threw his batting gloves at an umpire and got a much longer suspension than Manny Machado.Did @MLBUA’s angry statement work?➡️ https://t.co/DTIBiWAkQs pic.twitter.com/SehonuHdLw— Yahoo Sports MLB (@MLByahoosports) June 21, 2019In a statement, Joe Torre, chief baseball officer for MLB, cited Cabrera’s suspension for “throwing equipment from the dugout at Major League Umpire Bill Miller.”The punishment handed to Cabrera seems rather harsh given that Padres star Manny Machado was only suspended one game earlier this week for a confrontation with an umpire in which Machado threw his bat. Cabrera also allegedly bumped the umpire in his incident. MLB trade rumors: Yankees’ Brian Cashman would do ‘whatever it takes’ to land Max Scherzer Cabrera was ejected by home plate umpire Bill Miller in the sixth inning. After taking a borderline inside pitch for strike three, Cabrera went to the dugout. After reviewing a replay of the pitch, Cabrera yelled at Miller “Let’s f—ing go, that’s inside pitch!”After Miller issued a warning, Cabrera threw his batting gloves in Miller’s direction, earning the ejection. Related News That suspension drew a sharply worded statement from the MLB Umpires Association calling for MLB to step up discipline for players involved in disputes with umpires. MLB responded with a statement later that day saying in part, “We do not believe it is appropriate for the union representing Major League Umpires to comment on the discipline of players …”The 33-year-old Cabrera is slashing .242/.322/.428 with 11 home runs in 67 games in his first season with the Rangers.last_img read more

FC Sarajevo celebrated in Lukavica

first_imgPlayers of FC Sarajevo recorded an important victory in the 25th round of the Football Premier League of Bosnia and Herzegovina and regained the leading position.“Maroon“ team won against the FC Slavija in Lukavica with a result of 3:2 in last minutes of the match and on that way, succeeded to win three important games in a race for winning a title of champion of Bosnia and Herzegovina.Sarajevo arrived to Lukavica with an intention to win three points and regain the leading position, while on the other hand, Slavija needed points to ensure the survival in the company of the best ones.In a difficult match, FC Sarajevo justified the role of favorites, although host players offered a worthy resistance. Guests led in the 4th minute by the goal of Leon Benko, but Slavija equalized seven minutes later with a goal of Hodzurda.Host led in the 31st minute with a nice shot of Radosavljevic from the free kick. First half has been finished with the result of 2:1 for Slavija.Guests came to the equalizing goal in the 61st minute by Velkoski, after which the math was abandoned for 20 minutes due to riots on the stands.Until the end of the match, both teams had a good chances for new goals, but winning goal and new points in a race for the title of champion of BiH scored Milos Stojcev in the injury time, when it seemed that the match will finish with no winner.(Source: novovrijeme.ba)last_img read more

Dale Duane Meyer, 90, Wellington: Dec. 21, 1924 – Sept. 3, 2015

first_imgDale DuaneDale Duane Meyer, age 90, beloved husband, father, grandfather and friend, passed away early Thursday morning, September 3, 2015.Dale Duane Meyer was born December 21, 1924 in Wellington to Herman Frank Meyer and Nora Pearl (Rowe) Meyer. Dale lived in Wellington his entire life. He graduated from Wellington High School with the class of 1942.On September 3, 1946 in Wellington, KS, Dale married Georgia J. Shields, beginning a 69 year union filled with joy, friendship and happiness. Together they raised three daughters.Dale served in WWII in the 3rd Radio Squadron Mobile, Det. A., 9th Army Air Corps in Europe. He worked for the Santa Fe Railroad as a telegrapher for over 40 years and retired in 1986.  He was a member of the American Legion, Elks Club and First United Methodist Church.Dale’s lifelong gardening hobby resulted in many years of beautiful flowers and vegetables that were much appreciated by family and friends.He was preceded in death by his parents.Dale is survived by his loving wife, Georgia of the home; three daughters and their spouses, Janet Janeen (John) Eubank of Wichita, KS, Denise Daleen Meyer and her companion (Joe Mollure) of Corona, CA, and Melissa Ann (Michael) Hamlin of Park City, KS; he was a wonderful and caring grandfather to Jason Eubank and Jena Eubank Cantwell both of Wichita, KS, Shanda Arrowsmith Baker of Dallas, TX, Aubrey Anna Bush and Adam Spaid both of Park City, KS, Jill Hamlin Dickinson of Wellington, KS, and Scott Hamlin of Wichita, KS; he was a great grandfather to Olivia and Tess Eubank, Avery Cantwell, Ariel and Ashton Craine, Hayden and Leah Kate Bush, Addison Noelle and Abbigail Georgia Spaid, Devin and Dylan Dickinson and Emmett Hamlin.Military Graveside Services will be held at the Sumner Memorial Gardens on Friday, September 11, 2015 at 11:00 A.M.  Chaplain Doug Smith will officiate.Cremation has taken place.Friends can sign the register book at the funeral home on Thursday, September 10, 2015 from 1:00-8:00 P.M.A memorial has been established with the Juvenile Diabetes Association.  Contributions can be left at the funeral home.Frank Funeral Home has been entrusted with the arrangements.To leave condolences or sign our guest book, please visit our website at www.frankfuneralhome.netlast_img read more